The abstract begins, "Growing evidence supports early eating to control appetite and energy balance". What does that mean? My unskilled reading of it is that there is recent evidence that eating breakfast helps with weight loss. But I'm confused because there was a 2019 meta-analysis that found that eating breakfast does NOT help with weight loss. https://www.bmj.com/content/364/bmj.l42
You might want to read the rest of the studies - or at least try to no misrepresent before commenting. There are elementary differences in the studies.
Study 1: "What to Eat", Specific Demographics, Primary Clinical Trial, Mechanistic/Physiological Outcome, Conclusion: High-Protein breakfast is superior for suppressing appetite and maintaining satiety, while a High-Fiber breakfast promotes better weight loss and a healthier gut microbiome,
Study 2: Whether to Eat, Broad Demographics, Systematic Review (meta analysis), Broad Clinical Outcomes, Conclusion: eating breakfast increases total daily energy intake compared to skipping it, and that skipping breakfast resulted in slightly greater weight loss.
We saw this effect in a small study, so it's worth doing a larger study.
It's worth publishing because it's evidence and motivation to do further studying. And if you're asking "Why not start large?" the answer is obvious: money.
Especially in dietary studies. You either spend a lot on high quality, controlled studies where you can nail down parameters (takes a LOT of labour), or you spend on facilitating much larger studies where you make up for precision and control with volume.
There are trade offs in either case and some types of research where one is more suitable than the other. But the best case is a combination of the two, and it's exceedingly rare.
Maybe there are other options but this seems to be the polar nature of these studies from what I've seen.
The paper includes a section on power analysis which justifies the sample size (although the justification is for a sample of 20, they recruited 25 eligible participants and lost 6 in screening).
Some points though:
- A within-participants study has inherently more power than a between-subjects study. Trying two different diets with the same person removes a lot of variables that you'd need to control for in between-subjects studies (and yes, they randomized the order of intervention and found no difference based on order)
- It looks like this was conducted in a way that supported compliance with the protocol, and using analysis techniques that would be unwieldy for a much larger sample size.
Even with N=19, the reported significance is very compelling.
The number needed for a study to get significant results depends on the strength of the effect it is measuring.
For example if I have a bag full of thousands of coins, pull out 19 at random and flip them sequentially, and they all come out heads I'm going to conclude I have a bag that is overwhelmingly coins that are heavily biased toward coming up heads.
Are you going to say my sample size was too small to support that conclusion?
To see if their sample size was too small you need to at least read the part where they do the math.
Buddha recommended to his followers a diet which consisted of a breakfast and a second meal at noon if needed. That is, for their health, primary meal early in the day and fasting the remainder. It's interesting that this advice seems fairly supported by science.
They used a crossover design, so each subject served as their own control. Not a bad choice for trials like this as you gain a lot of statistical power with fewer participants than a parallel-arm, non-crossover design.
I don't think they used crossover design. There is no evidence in the abstract that they used crossover design.
If they used crossover design they should have all participants go through a second trial period where they consume the same diet but with light breakfast and more caloric lunch and dinner. Then they could actually have more insight on the main thesis of their study, i.e. whether bug breakfast alters appetite.
They did a crossover study on the two diets. Ie the high protein diet and the high fiber diet. They did absolutely no crossover or no control on the headline thesis of their paper. The headline being that big breakfast alters appetite or is somehow good for weight-loss.
This study shows or proves absolutely nothing about advantages or disadvantages of big breakfast or that a big breakfast makes any difference whatsoever.
It only shows that if you are going to have a big breakfast as part of calorie limited diet if you choose a diet with high protein you will lose weight slightly faster but will have slightly worse gut health than if you chose a diet with high fructose.
I feel like the regular weight loss group was? Since it isn't necessarily rocket science for having mostly men stay in an easily determinable caloric deficit to lose weight. (Women have usually would be harder due to more conditions and hormone interactions that make finding a TDEE not as simple.)
TLDR: A weight loss diet centered around a big breakfast yields weight loss results. That breakfast loaded with protein made you feel fuller and suppressed your appetite (which helps you follow a diet), where a fiber loaded diet produced more beneficial gut bacteria.
The study has a pretty small sample size, but it seems well designed and matches what you'd expect.
Study 1: "What to Eat", Specific Demographics, Primary Clinical Trial, Mechanistic/Physiological Outcome, Conclusion: High-Protein breakfast is superior for suppressing appetite and maintaining satiety, while a High-Fiber breakfast promotes better weight loss and a healthier gut microbiome,
Study 2: Whether to Eat, Broad Demographics, Systematic Review (meta analysis), Broad Clinical Outcomes, Conclusion: eating breakfast increases total daily energy intake compared to skipping it, and that skipping breakfast resulted in slightly greater weight loss.
How many of these studies used buttered eggs and potato as the sole breakfast?
Who in their own mind decided that this is a "study" worth publishing?
You read
In actuality it is It's worth publishing because it's evidence and motivation to do further studying. And if you're asking "Why not start large?" the answer is obvious: money.There are trade offs in either case and some types of research where one is more suitable than the other. But the best case is a combination of the two, and it's exceedingly rare.
Maybe there are other options but this seems to be the polar nature of these studies from what I've seen.
Some points though:
- A within-participants study has inherently more power than a between-subjects study. Trying two different diets with the same person removes a lot of variables that you'd need to control for in between-subjects studies (and yes, they randomized the order of intervention and found no difference based on order)
- It looks like this was conducted in a way that supported compliance with the protocol, and using analysis techniques that would be unwieldy for a much larger sample size.
Even with N=19, the reported significance is very compelling.
For example if I have a bag full of thousands of coins, pull out 19 at random and flip them sequentially, and they all come out heads I'm going to conclude I have a bag that is overwhelmingly coins that are heavily biased toward coming up heads.
Are you going to say my sample size was too small to support that conclusion?
To see if their sample size was too small you need to at least read the part where they do the math.
Countries known for light or skipped breakfasts: France, Japan, China.
I think I'll wait for a more thorough study.
It was high fiber big breakfast vs high protein big breakfast.
(And no, this comment was not written by an LLM).
If they used crossover design they should have all participants go through a second trial period where they consume the same diet but with light breakfast and more caloric lunch and dinner. Then they could actually have more insight on the main thesis of their study, i.e. whether bug breakfast alters appetite.
This study shows or proves absolutely nothing about advantages or disadvantages of big breakfast or that a big breakfast makes any difference whatsoever.
It only shows that if you are going to have a big breakfast as part of calorie limited diet if you choose a diet with high protein you will lose weight slightly faster but will have slightly worse gut health than if you chose a diet with high fructose.
Why not add a third high-fiber + high-protein group for example?
Soon we will have more participants in the HN comments for the study, than were studied in the study.
The study has a pretty small sample size, but it seems well designed and matches what you'd expect.
I'll see myself out.